Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 32, Issue 3, Pages 205-209Publisher
WILEY
DOI: 10.1111/j.1574-695X.2002.tb00555.x
Keywords
lymphopenia; insulin-dependent diabetes mellitus; BioBreeding rat; bacteriophage Phi X174
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Funding
- NIAID NIH HHS [AI42380] Funding Source: Medline
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Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast. the secondary immune response. expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9 +/- 3.2; mean value +/- S.E.M. for seven rats) compared to both Lyp/+ (51 +/- 12; n = 13; P = 0.006) and +/+ (100 +/- 20; n = 7 : P = 0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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