Journal
JOURNAL OF CONTROLLED RELEASE
Volume 79, Issue 1-3, Pages 29-40Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(01)00549-1
Keywords
macrophages; targeting; liposomes; microspheres; physicochemical properties
Ask authors/readers for more resources
heterogeneous functions of macrophages in human immune systems have renewed interest in targeting of drugs to these cells. Various carrier systems have emerged to deliver drugs to macrophages, albeit the efficacy, reliability and selectivity of these carriers are still in question. To date, the most extensively studied carriers are liposomes and microspheres. Various physicochemical properties of these carriers can alter their efficacy and specificity to a great extent. These properties include hydrophilicity, surface charge, composition, concentration. and presence of various ligands. In this review, a comprehensive evaluation of the literature has been carried out in order to show the role of these parameters in the design of carriers for targeting of drugs to macrophages. (C) 2002 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available