Journal
FEBS LETTERS
Volume 513, Issue 1, Pages 114-118Publisher
WILEY
DOI: 10.1016/S0014-5793(01)03244-6
Keywords
actin cytoskeleton; cell adhesion; focal adhesion; integrin signaling
Funding
- NIGMS NIH HHS [R01 GM047607] Funding Source: Medline
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Adapter/scaffold proteins, through their multidomain structure, perform a fundamental role in facilitating signal transduction within cells. Paxillin is a focal adhesion adapter protein implicated in growth factor- as well as integrin-mediated signaling pathways. The amino-terminus of paxillin contains five leucine-rich sequences termed LD motifs. These paxillin LD motifs are highly conserved between species as well as within the paxillin superfamily. They mediate interactions with several structural and regulatory proteins important for coordinating changes in the actin cytoskeleton associated with cell motility and cell adhesion as well as in the regulation of gene expression. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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