Journal
FEBS LETTERS
Volume 513, Issue 1, Pages 2-10Publisher
WILEY
DOI: 10.1016/S0014-5793(01)03292-6
Keywords
protein-protein interactions; phosphorylation-dependent binding; SH2 domains; signal transduction
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Many of the signaling pathways and regulatory systems in eukaryotic cells are controlled by proteins with multiple interaction domains that mediate specific protein-protein and protein-phospholipid interactions, and thereby determine the biological output of receptors for external and intrinsic signals. Here, we discuss the basic features of interaction domains, and suggest that rather simple binary interactions can be used in sophisticated ways to generate complex cellular responses. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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