Journal
FEBS LETTERS
Volume 513, Issue 1, Pages 58-66Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)03294-X
Keywords
phosphorylation; signal transduction; protein : protein interaction; kinase; forkhead-associated domain; kinesin; checkpoint; DNA repair
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The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes. It is also found in a number of bacterial proteins. This suggests that FHA domain-mediated phospho-dependent assembly of protein complexes is an ancient and widespread regulatory mechanism. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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