Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 499, Issue 2, Pages 143-150Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0027-5107(01)00284-6
Keywords
minisatellite; ionising radiation; mutation induction
Ask authors/readers for more resources
The analysis of the effects of ionising radiation on germline mutations is limited by the number of offspring that need to be analysed following exposure to a dose, which is relevant to risk assessment in humans. We have developed a new experimental approach using hypervariable mouse expanded simple tandem repeat (ESTR) loci (minisatellites) which are both highly sensitive to ionising radiation and which permit changes in mutation rates to be detected in relatively small samples. Here, we review the progress made in validating the model, and the unexpected features it has revealed, including a novel form of radiation-induced genetic instability that can be transmitted from one generation to the next. (C) 2002 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available