Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 54, Issue 2, Pages 223-233Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-409X(02)00018-2
Keywords
gene delivery; gene therapy; DNA; polycation; block copolymer; poly(ethylene glycol)
Categories
Ask authors/readers for more resources
Pluronic(R) block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. They have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and polypeptides. This review describes novel applications of Pluronic block copolymers in gene therapy. In particular, these molecules can modify the biological response during gene therapy in the skeletal muscle, resulting in an enhancement of the transgene expression as well as an enhancement of the therapeutic effect of the transgene. Furthermore, Pluronic(R) block copolymers are versatile molecules that can be used as structural elements of the polycation-based gene delivery systems (polyplexes). Based on these studies, the use of block copolymers in gene delivery is a promising area of research, in which new and important developments are expected. (C) 2002 Elsevier Science B V All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available