Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 768, Issue 1, Pages 113-119Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-4347(01)00498-4
Keywords
drug-protein binding; thermodynamic equilibrium; Bjerrum plot; S-propafenone; alpha(1)-acid glycoprotein; reviews
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This contribution focuses the reader's attention on the pitfalls usually emerging during the phase of evaluation of experimental data of drug-protein binding studies. To overcome the occurrence of problem(s) apparently defying solution, the concept of affinity spectra is recommended to be implemented for data evaluation. A (general) binding study protocol is also suggested, which can prevent the formation of inadequate conclusions and the generation of unrealistic drug-protein binding parameters. (C) 2002 Elsevier Science B.V. All rights reserved.
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