Journal
AUSTRALIAN JOURNAL OF CHEMISTRY
Volume 66, Issue 2, Pages 157-164Publisher
CSIRO PUBLISHING
DOI: 10.1071/CH12426
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Funding
- Novartis-MIT Center for Continuous Manufacturing
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A new photochemical flow reactor has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2'-deoxy and 2',3'-dideoxynucleosides. The continuous flow format significantly improved both the efficiency and selectivity of the reaction, with the streamlined multi-step sequence directly furnishing the highly desired unprotected deoxynucleosides.
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