Journal
AUSTRALIAN JOURNAL OF CHEMISTRY
Volume 65, Issue 7, Pages 883-891Publisher
CSIRO PUBLISHING
DOI: 10.1071/CH12042
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Funding
- Australian Research Council
- Monash University
- Victorian Government's Operational Infrastructure Support Program
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Two new substituted thiobenzoic acids, m-nitrothiobenzoic and m-sulfothiobenzoic acid, and six (four new) homo- and heteroleptic bismuth(III) compounds derived from thiobenzoic acid and substituted thiobenzoic acid have been synthesised and fully characterised using both solvent free and solvent mediated methods; Bi(SC(=O)C6H5)(3) (3), PhBi(SC(=O) C6H5)(2) (4), Ph2Bi(SC(=O)C6H5) (5), Bi(SC(=O)C6H4-m-NO2)(3) (6), PhBi(SC(=O)C6H4-m-NO2)(2) (7), and PhBi(SC (=O)C6H4-m-SO3) (8). The solid-state structures of the previously reported Bi(SC(=O)C6H5)(3) (3) and PhBi(SC(=O)] C6H5)(2) (4) complexes have now been confirmed by X-ray crystallography. In the solid-state complex 3 forms a column-like polymeric structure resembling stacked bowls through pyramidal intermolecular Bi-S-3 bonds of distance 3.359 angstrom, providing a Bi(III) centre with a nine coordinate environment. Complex 4 forms discrete tetrameric units cemented by long intermolecular Bi-S (3.774 angstrom), Bi-O(=C) (3.030, 3.071 angstrom) and Bi-C bonds (3.627 angstrom). The complexes were assessed for their activity against three strains of Helicobacter pylori and all show a minimum inhibitory concentration of 6.25 mu g mL(-1), indicating that the high level of bactericidal activity is insensitive to the degree of substitution at the Bi(III) centre.
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