Journal
BRITISH JOURNAL OF CANCER
Volume 86, Issue 5, Pages 774-778Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6600197
Keywords
chemoprevention; resveratrol; piceatannol; cytochrome P450; CYPIBI
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Resveratrol is a cancer preventative agent that is found in red wine. Piceatannol is a closely related stilbene that has antileukaemic activity and is also a tyrosine kinase inhibitor, Piceatannol differs from resveratrol by having an additional aromatic hydroxy group. The enzyme CYPIBI is overexpressed in a wide variety of human tumours and catalyses aromatic hydroxylation reactions. We report here that the cancer preventative agent resveratrol undergoes metabolism by the cytochrome P450 enzyme CYPIBI to give a metabolite which has been identified as the known antileukaemic agent piceatannol. The metabolite was identified by high performance liquid chromatography analysis using fluorescence detection and the identity of the metabolite was further confirmed by derivatisation followed by gas chromatography-mass spectrometry studies using authentic piceatannol for comparison. This observation provides a novel explanation for the cancer preventative properties of resveratrol. It demonstrates that a natural dietary cancer preventative agent can be converted to a compound with known anticancer activity by an enzyme that is found in human tumours, importantly this result gives insight into the functional role of CYPIBI and provides evidence for the concept that CYPIBI in tumours may be functioning as a growth suppressor enzyme. (C) 2002 Cancer Research UK.
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