Journal
JOURNAL OF CELL BIOLOGY
Volume 156, Issue 5, Pages 771-774Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200111073
Keywords
NFAT; development; adaptation; calcium signaling; cell fate
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Funding
- NIAMS NIH HHS [AR-47314, R01 AR047314] Funding Source: Medline
- NIDCR NIH HHS [DE-13040] Funding Source: Medline
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The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system. This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types.
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