Journal
AUSTRALIAN JOURNAL OF CHEMISTRY
Volume 63, Issue 6, Pages 895-900Publisher
CSIRO PUBLISHING
DOI: 10.1071/CH10053
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Funding
- National Cancer Institute of Canada
- Canadian Institute for Health Research [MOP-84539]
- Aquinox Pharmaceuticals
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Four new diterpenoids, australins E-H (1-4), have been isolated from the marine soft coral Cladiella sp. collected in Pohnpei. The structures of 1-4 were elucidated by analysis of their NMR and mass spectrometry data combined with an X-ray diffraction analysis of australin E (1). Australin E (1) activates the inositol 5-phosphatase SHIP1 in vitro.
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