Journal
ORGANIC LETTERS
Volume 4, Issue 5, Pages 671-673Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol016737q
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[GRAPHICS] Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH2Cl2 extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Alkanthomycin was characterized using X-ray crystallography and NMR.
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