Journal
ORGANIC LETTERS
Volume 4, Issue 5, Pages 765-768Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol017240j
Keywords
-
Categories
Ask authors/readers for more resources
[GRAPHICS] A new and general four-step synthesis of protected alpha-substituted and alpha,alpha-disubstituted amino acids has been developed. The key step involves intramolecular ammonium ylide generation from a copper carbenoid with concomitant [2,3] rearrangement. The aromatic template serves as a tether, protecting group, and activating group for peptide coupling. The ylide rearrangement products can be converted into protected cyclic amino acids by ring-closing metathesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available