Journal
AUSTRALIAN JOURNAL OF CHEMISTRY
Volume 63, Issue 8, Pages 1210-1218Publisher
CSIRO PUBLISHING
DOI: 10.1071/CH10127
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Funding
- Australian Research Council (ARC) [DPO771155]
- Centre for Advanced Macromolecular Design (CAMD)
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Core-shell nanoparticles have been synthesized by core crosslinking of micelles. The underlying block copolymer, poly(oligo(ethylene glycol methyl ether methacrylate))-block-polystyrene (POEGMA-b-PS), was synthesized successfully by the reversible addition-fragmentation chain transfer (RAFT) process, using POEGMA as a macro-RAFT agent. The block copolymers were self-assembled into micelles in aqueous media and the resulting micelles and the RAFT endgroup, located in the core of the micelle, were used for the subsequent crosslinking step using a crosslinker, divinyl benzene (DVB). The rate of the crosslinking reaction was found to be slow with less than 20% conversion being achieved after 72 h. Nevertheless, crosslinked micelles were obtained and only a small fraction of free block copolymers remained. Cytotoxicity tests confirmed the biocompatibility of the prepared core-crosslinked micelles. In addition the crosslinked micelles were taken up by L929 cells without causing any signs of cell damage.
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