Journal
AUSTRALIAN JOURNAL OF CHEMISTRY
Volume 61, Issue 9, Pages 718-724Publisher
CSIRO PUBLISHING
DOI: 10.1071/CH08162
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Funding
- University of Aveiro, Fundacao para a Ciencia e a Tecnologia, and Fundo Europeu de Desenvolvimento Regional (FEDER) [POCI/QUI/59284/2004]
- FEDER [POCI/QUI/59284/2004]
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Novel 3-alkyl-3 ',4 ',5,7-tetrahydroxyflavones have been prepared. The synthetic strategy involves the preparation of 1-(2hydroxy-4,6-dimethoxyphenyl)alkan-1-ones from the Friedel-Crafts acylation of phloroglucinol followed by methylation. These key compounds were submitted to the three-step Baker-Venkataraman method, giving the 3-alkyl-3',4',5,7-tetramethoxyflavones, which were demethylated with boron tribromide.
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