Journal
SCIENCE
Volume 295, Issue 5562, Pages 2097-2100Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1068440
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- NHLBI NIH HHS [HL03979] Funding Source: Medline
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T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunatety, alloreactive T cells also cause graft-versus-host disease (GVHD). T cell depletion prevents GVHD but increases the risk of graft rejection and leukemic relapse. in human transplants, we show that donor-versus-recipient natural killer (NK)-cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD. In mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GVHD. NK cell alloreactivity may thus provide a powerful tool. for enhancing the efficacy and safety of allogeneic hematopoietic transplantation.
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