Journal
BRITISH JOURNAL OF CANCER
Volume 86, Issue 6, Pages 912-916Publisher
SPRINGERNATURE
DOI: 10.1038/sj.bjc.6600172
Keywords
caveolin-1; immunohistochemistry; thyroid carcinoma
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Caveolin-I is a major structural component of caveolae, which are plasma membrane microdomains implicated in the regulation of intracellular signalling pathways. Previous in vitro and in vivo studies on the function of caveolin-I in carcinoma showed controversial results, indicating that the physiological role of caveolin-I varies according to the origin of carcinoma. In this study, we investigated caveolin-I expression in thyroid neoplasms by means of immunohistochemistry using a rabbit polyclonal antibody against caveolin-I. Normal follicular cells did not express caveolin-I. In papillary carcinoma, caveolin-I expression was observed in high incidence, and especially in microcancer (less than 1,0 cm in diameter), caveolin-I was positive in all cases except one. In undifferentiated (anaplastic) carcinoma, its incidence was significantly reduced. On the other hand, all cases of follicular carcinoma and adenoma were classified as negative for caveolin-I. These results suggest that caveolin-I may play a role predominantly in the early phase of papillary carcinoma, whereas it has little influence on follicular tumours. (C) 2002 Cancer Research UK.
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