Journal
ORGANIC LETTERS
Volume 4, Issue 6, Pages 969-971Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol025537r
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- NIGMS NIH HHS [GM-31278] Funding Source: Medline
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[GRAPHICS] The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the a-p-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.
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