Journal
SCIENCE
Volume 295, Issue 5563, Pages 2255-2258Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1068819
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Funding
- NCRR NIH HHS [R01 RR013601-04, R01 RR013601, RR13601] Funding Source: Medline
- NHLBI NIH HHS [R01 HL064560-04, HL64560, R01 HL064560] Funding Source: Medline
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To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2(+) T cell responses to mycobacterial infections. These phosphoantigen-specific gammadelta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guerin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma2Vdelta2(+) T cells were also seen during Mycobacterium tuberculosis infection of naive and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2(+) T cells may contribute to adaptive immunity to mycobacterial infections.
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