Journal
BRAIN RESEARCH
Volume 931, Issue 1, Pages 68-73Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)02263-1
Keywords
neuroprotection; niacinamide; stroke; Poly(ADP ribose polymerase inhibitor; hypertension; diabetes
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Funding
- NINDS NIH HHS [NS 01732] Funding Source: Medline
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Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo). Intravenous NAm given 2 h after MCAo significantly reduced the infarct volume of SHR (750 mg/kg, 31%, P<0.01) and diabetic (500 mg/kg, 56%, P<0.01) as well as non-diabetic (500 mg/kg, 73%, P<0.01) Fischer 344 rats when compared with saline-injected controls. Thus delayed treatment with NAm protected hypertensive and hyperglycemic rats against a robust model of stroke. (C) 2002 Elsevier Science B.V. All rights reserved.
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