Journal
TOXICOLOGY LETTERS
Volume 129, Issue 1-2, Pages 33-45Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0378-4274(01)00467-2
Keywords
polycyclic aromatic hydrocarbons; benzo(a)pyrene; behavioral changes; neurotoxic effects; metabolism
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Funding
- NCRR NIH HHS [5G12RR03032-17] Funding Source: Medline
- NHLBI NIH HHS [T32-HL07809] Funding Source: Medline
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The behavioral changes caused by benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH) compound. were monitored, and also its metabolite levels in cerebellum and cortex were measured in BaP treated rats to see if any relationship existed between these two aspects. Rats were administered 0, 25, 50. 100. and 200 mg/kg of BaP in peanut oil by oral gavage. Plasma, and brain tissue (cerebellum and cortex) samples were collected at 0. 2, 4. 6. 12. 24, 48, 72 and 96 h post administration. Neurotoxic effects peaked at 2 h after dosing and lasted 48 h after dosing for all dose groups. The metabolite levels remained the same from 2 to 4 h, reached a peak at 6 h post gavage and showed a gradual decline returning to baseline levels at 72 h when the motor activity of treatment groups also returned to control levels. indicating recovery from the effects or BaP. A significant (P < 0.05) correlation between neurotoxic effects and BaP plasma. and brain metabolite concentrations suggests that metabolism plays an important role in modulating the neurobehavioral effects of BaP. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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