Journal
NEUROREPORT
Volume 13, Issue 4, Pages 501-505Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200203250-00029
Keywords
bipolar disorder; CaM kinase II; mRNA; prefrontal cortex; postmortem
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Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays critical roles in neurotransmission, synaptic plasticity, learning and memory. The aim of this study was to examine, by in situ hybridization, prefrontal cortical expression of CaMKII alpha mRNA in postmortem brains of unipolar, bipolar, schizophrenic, and control subjects. Compared to controls, bipolar patients had significantly lower levels of CaMKII cc m RNA in laminae I-VI of Brodmanns area 9 and laminae I-Ill and A of area 46. Unipolar patients also exhibited significantly lower levels of CaMKII alpha mRNA in laminae I-IV of area 9 than did controls. The significant decrease in CaMKII a mRNA in bipolar patients could be associated With some of the affective and cognitive alterations that have been linked to prefrontal cortical dysfunction in bipolar disorder, although this requires further direct examination.
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