4.4 Article

Facile synthesis of enantiopure (-)-TAN1251A

Journal

TETRAHEDRON LETTERS
Volume 43, Issue 13, Pages 2411-2414

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)00296-4

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Formal total synthesis of enantiopure (-)-TAN125lA, a muscarinic M, receptor antagonist, was achieved via a spirocyclic carbon-nitrogen bond formation by the use of aromatic oxidation with bis(acetoxy)iodobenzene as a key step. (C) 2002 Elsevier Science Ltd. All rights reserved.

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