Journal
FEBS LETTERS
Volume 515, Issue 1-3, Pages 1-7Publisher
WILEY
DOI: 10.1016/S0014-5793(02)02425-0
Keywords
Gab; tyrosine phosphorylation; receptor tyrosine kinase; signal transduction; differentiation
Funding
- NCI NIH HHS [CA6608, CA6648] Funding Source: Medline
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Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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