Journal
CANCER LETTERS
Volume 177, Issue 2, Pages 119-124Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(01)00708-X
Keywords
anti-tumor promotion; EBV-EA activation assay; acetophenone; Caesalpinia ferrea; gallic acid; methyl gallate
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The anti-tumor promoting effects of fruits of Caesalpinia ferrea MART. (Leguminosae) were tested by the in vitro Epstein-Barr virus early antigen (EBV-EA) activation assay, and its active constituents were identified as gallic acid (1) and methyl gallate (2). A total of 49 related compounds of 1 and 2 were analysed for the effects by this assay, and the structure activity relationships have been proposed. Three acetophenone derivatives, 2,6-dihydroxyacetophenone (48), 2,3,4-trihydroxyacetophenone (50) and 2,4,6-trihydroxy- acetophenone (51) were found to show potent inhibitory activity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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