Journal
TETRAHEDRON LETTERS
Volume 43, Issue 14, Pages 2609-2611Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)00313-1
Keywords
solution-phase synthesis; combinatorial chemistry; copper catalysis; tetrahydrofurans
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A large array of 3-methylene tetrahydrofurans has been synthesized from propargylic alcohols and activated olefins. The reaction is promoted by copper iodide that is removed at the end of the reaction by simple filtration, affording the desired heterocycles in high yield and purity. (C) 2002 Elsevier Science Ltd. All rights reserved.
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