Journal
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Volume 53, Issue 4, Pages 393-397Publisher
WILEY
DOI: 10.1046/j.1365-2125.2002.01366.x
Keywords
CYP2C 19; interaction; moclobemide
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Aims The pharmacokinetics of omeprazole and its metabolites in healthy subjects were evaluated to determine if a single dose of moclobemide inhibited CYP2C19 activity. Methods Sixteen volunteers, of whom eight were extensive metabolizers (EM) and eight were poor metabolizers for CYP2C19, participated in two studies. Venous blood samples were collected for 24 h after oral ingestion of 40 mg omeprazole with or without 300 mg moclobemide coadministration. The pharmacokinetic change of omeprazole, omeprazole sulphone and 5-hydroxyomeprazole concentrations were assessed to test for an interaction between omeprazole and moclobemide. Results The coadministration of moclobemide in EMs approximately doubled the mean AUC (front 1834 to 3760 ng ml(-1) h) and C-max (from 987 to 1649 ng ml(-1)) of omeprazole, and increased the AUC of omeprazole sulphone without changing AUC ratio of omeprazole to omeprazole sulphone. Moclobemide coadministration snore than doubled the AUC ratio of omeprazole to 5-hydroxyomeprazole (front 2.5 to 5.3) in EMs, too. There was a significant decrease in C-max and AUC of 5-hydroxyomeprazole in PMs but no significant changes were seen in the results for omeprazole and omeprazole sulphone AUCs. Conclusions A single dose of moclobemide resulted in significant suppression of CYP2C19 activity in EMs. We conclude that physicians prescribing moclobemide should pay attention to its pharmacokinetic interactions even oil the first day of coadministration with CYP2C19 substrates.
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