Journal
JOURNAL OF BACTERIOLOGY
Volume 184, Issue 8, Pages 2148-2154Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.184.8.2148-2154.2002
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- NIGMS NIH HHS [GM51127, R01 GM051127] Funding Source: Medline
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Expression of the two Bacillus subtilis genes encoding L-asparaginase is controlled by independent regulatory factors. The ansZ gene (formerly yccC) was shown by mutational analysis to encode a functional L-asparaginase, the expression of which is activated during nitrogen-limited growth by the TnrA transcription factor. Gel mobility shift and DNase I footprinting experiments indicate that TnrA regulates ansZ expression by binding to a DNA site located upstream of the ansZ promoter. The expression of the ansA gene, which encodes the second L-asparaginase, was found to be induced by asparagine. The ansA repressor, AnsR, was shown to negatively regulate its own expression.
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