Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 12, Issue 2, Pages 178-187Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(02)00284-8
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Funding
- NICHD NIH HHS [HD23844] Funding Source: Medline
- NIGMS NIH HHS [GM59772] Funding Source: Medline
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Significant portions of the eukaryotic genome are heterochromatic, made up largely of repetitious sequences and possessing a distinctive chromatin structure associated with gene silencing. New insights into the form of packaging, the associated histone modifications, and the associated nonhistone chromosomal proteins of heterochromatin have suggested a mechanism for providing an epigenetic mark that allows this distinctive chromatin structure to be maintained following replication and to spread within a given domain.
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