Journal
JOURNAL OF APPLIED TOXICOLOGY
Volume 35, Issue 10, Pages 1211-1218Publisher
WILEY
DOI: 10.1002/jat.3187
Keywords
graphene oxide; intravenous injection; biodistribution; toxicology
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Funding
- Ministry of Science and Technology (MOST), Taiwan [MOST 102-2221-E-134-001, MOST 103-2221-E-134-001]
- MOST of Taiwan
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Graphene and its functionalized derivatives have recently emerged as interesting nanomaterials with promising applications in biomedicine. In this study, the long-term in vivo biodistribution of intravenously injected nanographene oxide (NGO) functionalized with poly sodium 4-styrenesulfonate (PSS) was systematically examined and the potential toxicity over 6months of NGO-PSS nanoparticles was investigated. Our results showed that the nanoparticles mainly accumulate in the lung, liver and spleen, where they persist for at least 6months. These nanoparticles result in acute liver injury and chronic inflammation of the lung, liver and spleen, as evidenced by blood biochemistry results and histological examinations. Copyright (c) 2015 John Wiley & Sons, Ltd.
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