Journal
JOURNAL OF NATURAL PRODUCTS
Volume 65, Issue 4, Pages 487-491Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np010560r
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Funding
- NCI NIH HHS [CA71789-03] Funding Source: Medline
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Malevamide D (1), a highly cytotoxic peptide ester, and the known compound curacin D (5) were isolated from a Hawaiian sample of Symploca hydnoides. The structure of I was elucidated by spectroscopic analysis including NMR and high-resolution MS/MS. Partial stereochemical assignments of I were made by chiral HPLC analysis of acid and base hydrolysates. Malevamide D (1) demonstrated toxicity against P-388, A-549, HT-29, and MEL-28 cell lines in the subnanomolar range, while curacin D (5) was weakly cytotoxic. Malevamide D (1) is closely related to isodolastatin H (2), which was previously isolated in low yield from the sea hare Dolabella auricularia. A second Hawaiian sample of S. hydnoides yielded curacin D (5) along with the known dolastatin-10 analogue symplostatin-1 (3).
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