Journal
GROWTH HORMONE & IGF RESEARCH
Volume 12, Issue 2, Pages 84-90Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1054/ghir.2002.0265
Keywords
growth; metabolism; substrate phosphorylation; genetics; mouse models
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Receptor tyrosine kinases of the insulin-insulin-like growth factor (IGF) family promote growth and mediate metabolic signals. Despite their extensive structural homology, genetic evidence indicates that their physiological functions are distinct. Nevertheless, there is limited evidence from cell culture systems suggesting that their signalling capabilities differ. Thus, it remains unclear whether the different physiological roles of insulin and lGF-I receptors result from intrinsic differences in their abilities to activate distinct signalling pathways, or arise from extrinsic differences, such as tissue distribution, relative abundance and developmental regulation. (C) 2002 Elsevier Science Ltd. All rights reserved.
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