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Modulation of insulin signaling in human skeletal muscle in response to exercise

Journal

EXERCISE AND SPORT SCIENCES REVIEWS
Volume 30, Issue 2, Pages 85-90

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003677-200204000-00008

Keywords

insulin sensitivity; signal transduction; exercise training; PI 3-kinase; TNF-alpha

Funding

  1. NCRR NIH HHS [M01 RR-080] Funding Source: Medline
  2. NIA NIH HHS [AG-12834] Funding Source: Medline

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KIRWAN, J.P., and M. JING. Modulation of insulin signaling in human skeletal muscle in response to exercise. Exerc. Sport Sci. Rev., Vol. 30, No. 2, pp. 85-90, 2002. Exercise is widely recommended for the treatment of obesity, insulin resistance, and type II diabetes mellitus. Recent discoveries in the molecular and cellular regulation of insulin-mediated glucose metabolism in skeletal muscle have provided a deeper understanding of how exercise modulates insulin action.

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