Journal
EXPERIMENTAL GERONTOLOGY
Volume 37, Issue 4, Pages 603-605Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0531-5565(01)00219-4
Keywords
human prion disease; brain amyloidosis; prion protein
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Human prion diseases (PrD) preferentially manifest in the elderly. Their neuropathology may coexist with tau immunoreactive neuropil threads, neurofibrillary tangles, and beta-amyloid senile plaques, most likely representing an age-related change rather than a pathogenic link with Alzheimer's disease. Cerebrovascular disease with brain infarction, another malady preferring the elderly, is useful to prove the origin of PrD-associated prion protein deposition exclusively from neurons. (C) 2002 Elsevier Science Inc. All rights reserved.
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