Journal
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
Volume 47, Issue 6, Pages 564-568Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0004867413481631
Keywords
Bipolar disorder; depression; mania; N-acetyl cysteine; oxidative stress; remission; treatment
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Funding
- Stanley Medical Research Institute
- Mental Health Research Institute of Victoria
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Objective: Oxidative imbalance has emerged as a treatment target in bipolar disorder. As very limited data are available on the clinical use of antioxidants for mania, we report here results from a post hoc and exploratory subgroup analysis of a randomized, placebo-controlled trial of N-acetyl cysteine (NAC). Methods: This was a placebo-controlled, randomized, clinical trial assessing the effect of NAC over 24 weeks in mania or hypomania. Symptomatic and functional outcomes were collected over the study period. Results: Fifteen participants were available for this report; two participants in each group failed to complete all assessments. Within-group analyses pointed to an improvement in the NAC group on manic symptoms and worsening in the placebo group on depressive symptoms at endpoint. Conclusions: Although the sample size was small, these results indicated within-group efficacy for this glutathione precursor as compared to placebo. Future trials specifically designed to demonstrate the efficacy of NAC in mania are needed.
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