Journal
NUCLEIC ACIDS RESEARCH
Volume 30, Issue 7, Pages 1558-1562Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/30.7.1558
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Funding
- NIGMS NIH HHS [GM 57356] Funding Source: Medline
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We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.
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