Deterioration of previous acute lung injury during neutropenia recovery

Design: Although neutropenia recovery is associated with a high risk of deterioration of respiratory condition, no studies designed to identify risk factors for acute respiratory distress syndrome (ARDS) in this situation have been published. Setting: Medical ICU in a French teaching hospital. Subjects: We conducted a study to describe critically ill cancer patients with ARDS during neutropenia recovery (defined as the 7-day period centered on the day the neutrophil count rose above 1000/mm(3) [day 0]) and to compare them with critically ill cancer patients without ARDS during neutropenia recovery. Interventions: None. Measurements and Main Results: During a 10-yr period, 62 critically ill cancer patients recovered from neutropenia, of whom 21 experienced ARDS during neutropenia recovery, with a median time of -1 days (-2.5-1) between day 0 and ARDS. In-ICU mortality in these 21 patients was 61.9%. As compared with non-ARDS patients, ARDS patients were less likely to have myeloma and more likely to have leukemia/lymphoma treated with adriamycin, a history of pneumonia before neutropenia, and a neutropenia duration >10 days; they had a shorter time since malignancy diagnosis and a longer time from chemotherapy to neutropenia. Neither the leukocyte counts on day 0 nor those during the 6-day neutropenia recovery period were predictive of ARDS. Conclusions: Patients with acute respiratory failure after prolonged neutropenia complicated by pneumonia are at increased risk for ARDS. (Crit Care Med 2002; 30:781-786).