Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 7, Issue -, Pages D765-D783Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/matsumur
Keywords
photocarcinogenesis; ultraviolet; skin cancer; DNA repair; p53; Ptc. hedgehog pathway; p16(INK4a); p19(ARF); ras; review
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Funding
- NCI NIH HHS [R01-CA 46523] Funding Source: Medline
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Photocarcinogenesis represents the accumulation of genetic changes as well as immune system modulation, which ultimately lead to the development of skin cancers. The recent advances in molecular and cellular biology have clarified the mechanisms of photocarcinogenesis, including the formation of DNA photoproducts, DNA repair, mutation of proto-oncogenes and tumor suppressor genes, and UV-induced immunosuppression. The understanding and further investigation of photocarcinogenesis is critical to the development of effective prevention and intervention strategies for human skin cancer.
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