Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 47, Issue 4, Pages 629-633Publisher
WILEY
DOI: 10.1002/mrm.10135
Keywords
T-2 relaxation time; high magnetic field; Carr-Purcell spin echo; cerebral metabolites; adiabatic pulse
Funding
- NCI NIH HHS [CA79732] Funding Source: Medline
- NCRR NIH HHS [RR08079] Funding Source: Medline
- NINDS NIH HHS [NS38070, NS39043] Funding Source: Medline
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Carr-Purcell and Hahn spin-echo (SE) measurements were used to estimate the apparent transverse relaxation time constant (T-2(dagger)) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T-2(dagger) values of proton resonances (water, N-acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T-2(dagger) decay can be substantially reduced using a Carr-Purcell-type SE sequence. (C) 2002 Wiley-Liss, Inc.
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