Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 14, Issue 2, Pages 237-245Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(02)00312-5
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Recent investigation of the DNA-damage checkpoint in several organisms has highlighted the conservation of this pathway. The checkpoint's signal transduction pathway consists of four conserved classes of molecules: two large protein kinases having homology to phosphatidylinositol 3-kinases, three 'sensor' proteins with homology to proliferating cell nuclear antigen, two serine/threonine (S/T) kinases, and two adaptors for the S/T kinases. This review compares the role of these four classes of checkpoint proteins in humans and model organisms.
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