Successful treatment of refractory disseminated Mycobacterium avium complex infection with the addition of linezolid and mefloquine

Except in patients with AIDS, disseminated MAC infection has been rare. We describe a patient with chronic lymphatic leukemia who developed disseminated cutaneous MAC lesions refractory to conventional antimycobacterial therapy. The lesions responded to the addition of compounds that were recently discovered to have anti-MAC activity (linezolid, mefloquine, moxifloxacin) as well as GM-CSF. (C) 2002 The British Infection Society.