Journal
MOLECULAR IMAGING
Volume 1, Issue 2, Pages 82-88Publisher
B C DECKER INC
DOI: 10.1162/153535002320162732
Keywords
-
Funding
- Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation [DRG-1638]
- NIH [P50 CA86355, P01-CA69246, R33 CA88365, R24 CA 92782]
Ask authors/readers for more resources
Fluorescence imaging is increasingly used to probe protein function and gene expression in live animals. This technology could enhance the study of pathogenesis, drug development, and therapeutic intervention. In this article, we focus on three-dimensional fluorescence observations using fluorescence-mediated molecular tomography (FMT), a novel imaging technique that can resolve molecular function in deep tissues by reconstructing fluorescent probe distributions in vivo. We have compared FMT findings with conventional fluorescence reflectance imaging (FRI) to study protease function in nude mice with subsurface implanted tumors. This validation of FMT with FRI demonstrated the spatial congruence of fluorochrome activation as determined by the two techniques.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available