Gender does not influence the susceptibility of C57BL/6 mice to develop chronic experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), is more prevalent in females than males. It is well documented that a significant gender difference exits in the susceptibility I of mice to develop experimental autoimmune encephalomyelitis (EAE), a model of MS. induced by myelin basic protein or proteolipid protein. In contrast, we report here that no significant difference between female mice and male mice with myelin oligodendrocyte glycoprotein (MOG)-induced EAE was observed in the incidence of disease. clinical course. histological findings in the CNS, T cell response and cytokine production of spleen cells to MOG. and anti-MOG IgG level in serum. These results Suggest that gender-related difference in EAE depends on the encephalitogen and,or the strain of animals used. Given that MOG is a putative pathogenic myelin antigen in MS. the present Findings may have implications for the pathogenesis of this disease. (C) 2002 Elsevier Science B.V. All rights reserved.