Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 13, Issue 2, Pages 119-134Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6101(01)00022-3
Keywords
interferon-alpha; tumor; immunity; immunotherapy
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Interferon-alpha (IFN-alpha) is a pleiotropic cytokine belonging to type I IFN, currently used in cancer patients. Early studies in mouse tumor models have shown the importance of host immune mechanisms in the generation of a long-lasting antitumor response to type I IFN. Recent studies have underscored new immunomodulatory effects of IFN-alpha including activities on T and dendritic cells, which may explain IFN-induced tumor immunity. Reports on new immune correlates in cancer patients responding to IFN-alpha represent additional evidence on the importance of the interactions of IFN-a with the immune system for the generation of durable antitumor response, This knowledge, together with results from studies on genetically modified tumor cells expressing IFN-alpha, suggest novel strategies for using these cytokines in cancer immunotherapy and in particular the use of IFN-alpha as an immune adjuvant for the development of cancer vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.
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