Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 32, Issue 4, Pages 399-404Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0020-7519(01)00348-4
Keywords
helminth; signalling; transforming growth factor-beta; insulin; dauer; Haemonchus; Toxocara; Brugia; Strongyloides; Ancylostoma
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Funding
- NIAID NIH HHS [F32 AI10513] Funding Source: Medline
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The signal transduction pathways involved in regulating developmental arrest in the free-living nematode, Caenorhabditis elegans, are fairly well characterised. However, much less is known about how these processes may influence the developmental timing and maturation in helminth parasites. Here, we provide an overview of two signalling pathways implicated in the regulation of dauer larva formation in C. elegans, the insulin-like signalling pathway and the transforming growth factor-beta pathway, and explore what is known about these signalling pathways in a variety of parasitic helminths. Understanding the differences about how these pathways are affected by environmental cues in free-living versus parasitic species of helminths may provide insights into novel mechanisms for the control or prevention of helminth-induced disease. (C) 2002 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
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