Journal
CELL
Volume 109, Issue -, Pages S45-S55Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(02)00675-X
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V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.
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