Journal
TETRAHEDRON LETTERS
Volume 43, Issue 14, Pages 2657-2659Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)00280-0
Keywords
zirconium tetrachloride; beta-ketoesters; Biginelli reaction; dihydropyrimidinones
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Zirconium tetrachloride catalyzes efficiently the three component condensation reaction of an aromatic aldehyde, a beta-ketoester and urea in refluxing ethanol to afford the corresponding dihydropyrimidinone in high yield. (C) 2002 Elsevier Science Ltd. All rights reserved.
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