Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 46, Issue 4, Pages 1105-1107Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.4.1105-1107.2002
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Azithromycin and clarithromycin were paired with other antibiotics to test synergistic activity against 300 multidrug-resistant pathogens isolated from cystic fibrosis (CF) patients. Clarithromycin-tobramycin was most active against Pseudomonas aeruginosa and inhibited 58% of strains. Azithromycin-trimethoprim-sulfamethoxazole, azithromycin-ceftazidime, and azithromycin-doxycycline or azithromycin-trimethoprim-sulfamethoxazole inhibited 40, 20, and 22% of Stenotrophomonas maltophilia, Burkholderia cepacia complex, and Achromobacter (Alcaligenes)xylosoxidans strains, respectively.
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